Deadly piston pump: How a colonization factor is secreted by bacterial type 4 pili

Bacterial infectious diseases are still a huge contributor to global disease burden and with antibiotic resistance on the rise worldwide there is an urgent need for novel treatment strategies against bacteria. One of the most devastating bacterial infections is Cholera, caused by the bacteria Vibrio cholerae, which has been in its seventh ongoing pandemic since 1961. Now, a research group led by Osaka University in Japan has shed light on a specific protein interaction that has the potential to be a novel target in Cholera treatment.

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