Scientists show how bone-bordering cells may help shape a skull

A skull is not one single bone but rather a collection of bone plates joined together early in development. In a study of mice, scientists at the Icahn School of Medicine at Mount Sinai showed how the activity of one gene, turned on in a newly discovered group of bone-bordering cells, may play an important role in shaping the skull. The skulls of mice that were missing the gene were misshapen and were depleted of the cells in a manner that is reminiscent of craniosynostosis, a developmental disorder that affects about one out every 2,500 babies born in the United States.

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