High-resolution mapping method for G4 DNA structures developed

While investigating the unusual G quadruplex DNA structure (G4), the Simon Elsässer group has developed a more accurate method for mapping these structures in the genome. G4 CUT&Tag revealed numerous G4s in the human and mouse genome that were previously not detected. The study has been published in Nucleic Acid Research. These findings may be used for drug development for cancer therapy and provide an important tool to evaluate drug action and safety.

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