Study rewrites dogma of adenovirus infection and double-stranded RNA

Challenging the dogma of what scientists thought they understood about DNA viruses, a team of researchers led by Children's Hospital of Philadelphia (CHOP) has shown that adenovirus uses its own efficient RNA splicing mechanisms to prevent the formation of double-stranded RNA, which otherwise would trigger a host immune response. By splicing its RNA transcripts in a way that prevents them from pairing with other viral messages, adenovirus evades host sensors that activate the immune system in the presence of double-stranded RNA. The findings were published today as a "Breakthrough Article" in Nucleic Acids Research.

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