How to produce proteins at the right speed

In all eukaryotic organisms, genetic material is stored in the cell nucleus in the form of DNA. In order to be used, this DNA is first transcribed into messenger RNA in the cell cytoplasm, then translated into protein with the help of ribosomes, small machines capable of decoding messenger RNA to synthesize the appropriate proteins. However, the speed with which this mechanism takes place is not uniform: it must adapt to allow the protein to adopt the right configuration. Indeed, a deregulation of the production rate leads to structural defects. The proteins, which are not correctly folded will aggregate, become unusable and often toxic for the cell. By analyzing the rate of ribosome movement in yeast cells, a team from the University of Geneva (UNIGE), Switzerland, in collaboration with the University of Hamburg, has succeeded in demonstrating that the rate of protein synthesis is modulated by regulatory factors that modify at will the rate of translation of messenger RNA into proteins. These results can be found in the journal Cell Reports.

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