New method to analyze nucleosomes

Northwestern Medicine scientists have developed a new method to analyze the protein composition of intact nucleosomes without losing combinatorial information present in chromatin. The technique, called Nuc-MS, could help scientists more efficiently uncover the mechanisms behind mutation-driven diseases such as some cancers, according to Neil Kelleher, Ph.D., professor of Medicine in the Division of Hematology and Oncology, director of the Proteomics Center of Excellence and senior author of the study published in Nature Methods.

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