Researchers shed new light on DNA replication

In preparation for cell division, cells need to replicate the DNA that they contain. A team of researchers from TU Delft, collaborating with investigators from the Francis Crick Institute in London, has now shown that the protein building blocks involved in the initial steps of DNA replication are mobile but reduce their speed at specific DNA sequences on the genome. Their findings, which were published in the open-access journal Nature Communications on 26 March, were facilitated using an integrated approach involving biophysics and biochemistry that will propel new discoveries in the field.

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