Scientists identify new methylation site on P53 guided by structure of MLL2 complex

Lysine methylation is one of the most important covalent modifications involved in diverse cellular processes. Methylation of histone H3 Lys4 (H3K4), predominantly associated with actively transcribed genes, is mainly mediated by KMT2-family histone lysine methyltransferases (KMTs). The mammalian KMT2 family contains six members (MLL1–MLL4, SET1A and SET1B), each of which has crucial and non-redundant roles in cells.

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