Overcoming genomic imprinting barrier improves mammal cloning

Somatic cell nuclear transfer (SCNT, also known as cloning) technology holds great potential in animal production and regenerative medicine. However, the extremely low efficiency and frequently observed abnormalities in cloned embryos limit the development and application of this technology. Although the cloned embryos harbor complete genomic DNA sequence, multiple epigenetic barriers are the limiting factors of cloning efficiency.

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