How cells relieve DNA replication stress

DNA stores all of the information necessary for life phenomena, and a cell transmits its own genetic information to two daughter cells through DNA replication and cell division. Replication stress can be caused by extracellular and intracellular sources during DNA replication, which leads to slowed or stalled replication. If cells do not properly cope with such risks, chromosome break and rearrangement will occur, resulting in genomic instability. That helps explain why replication stress is one of the major contributors to cancer development.

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